TECHNOLOGY - Objective Preclinical Measures

  • Neural network activity is more conserved between animals and humans than are the corresponding behaviors
  • EEG monitoring of higher-order neuronal network oscillations is now being routinely performed in living animals at Galenea
  • Digitized behavioral testing that is fully integrated with these EEGs makes quantitative analyses possible
  • Initial modeling funded by $1M NIH grant
  • Goal is to move away from the poor predictive power of animal behavioral testing and to create models with much higher predictive power
  • Galenea has identified EEG signatures that discriminate between normal and disease mouse models (both genetic and pharmacological)

(Image, right.) Galenea has integrated computerized behavioral analysis with electroencephalographic (EEG) analysis to correlate animal behavior with EEG activity. Using this system, Galenea has identified disease-relevant EEG "signatures" that provide objective measures of drug efficacy based on neural network functions rather than outward behavioral signs.

In Vivo EEG